Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

J Dai, K Liang, S Zhao, W Jia, Y Liu… - Proceedings of the …, 2018 - National Acad Sciences
chemoproteomic profiling, we discovered that baicalin acts as a natural allosteric activator of
carnitine palmitoyltransferase 1 (CPT1)… By directly binding to CPT1 and activating its activity …

Uncovering the protective mechanism of baicalin in treatment of fatty liver based on network pharmacology and cell model of NAFLD

Y Wen, F Yi, J Zhang, Y Wang, C Zhao, B Zhao… - International …, 2024 - Elsevier
baicalin prevention and amelioration of fatty liver were AKT serine/threonine kinase 1 (AKT1),
peroxisome proliferator-activatedreveals the relationship between baicalin and fatty liver (…

The structure basis of phytochemicals as metabolic signals for combating obesity

X Li, L Zheng, B Zhang, ZY Deng, T Luo - Frontiers in Nutrition, 2022 - frontiersin.org
Baicalin has been reported to ameliorate high-fat diet-induced obesity and hepatic steatosis
through carnitine palmitoyltransferase 1 (CPT1) (150), of which mRNA serves as a potential …

The mechanisms of baicalin ameliorate obesity and hyperlipidemia through a network pharmacology approach

ZY Wang, ZM Jiang, PT Xiao, YQ Jiang, WJ Liu… - European Journal of …, 2020 - Elsevier
… Our study revealed that the anti-obesity mechanism of baicalin may be … Chemoproteomics
reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic

Research on the mechanism of regulating spleen-deficient obesity in rats by bawei guben huashi jiangzhi decoction based on multi-omics analysis

F Yi, W Wang, Y Yi, Z Wu, R Li, Y Song, H Chen… - Journal of …, 2024 - Elsevier
Baicalin, a variant carnitine palmitoyltransferase 1 activator, shows promise in ameliorating
diet-induced obesity and hepatic steatosis (Dai et al., 2018). Eriodictyol effectively prevents …

Quantitative proteomics reveals Polygonum perfoliatum L. ameliorates hepatic steatosis by promoting PPARs/CPT1A/CPT2-mediated fatty acid β-oxidation

G Liu, L Chang, Y Qian, J Lin, Z Shang, M Xu… - Frontiers in …, 2023 - frontiersin.org
… into the mitochondria via CPT1 and CPT2 located in both … liver tissues of PPL-treated mice
relative to the obese mice. In short, our results suggested that PPL notably activated hepatic

Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway

P Fang, Y Sun, X Gu, M Shi, P Bo, Z Zhang, L Bu - Phytomedicine, 2019 - Elsevier
… -fat diet-induced obese mice were given 50 mg/kg baicalin intraperitoneally (ip…
Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and …

[PDF][PDF] EFFECT OF BAICALIN ON THE INTESTINAL MICROBIOTA IN OBESE MICE INDUCED BY HIGH-FAT DIET.

JJ Li - Applied Ecology & Environmental Research, 2023 - aloki.hu
… (2018): Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced
obesity and hepatic steatosis. – Proceedings of the National Academy of Sciences of the …

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis.

DJY Dai JianYe, LK Liang Kai, ZS Zhao Shan… - 2018 - cabidigitallibrary.org
… The flavonoid directly activated hepatic CPT1 with isoform … of baicalin ameliorated diet-induced
obesity (DIO) and hepatic … Disruption of the predicted binding site of baicalin on CPT1

Baicalin attenuates diet-induced obesity partially through promoting thermogenesis in adipose tissue

H Li, S Tang - Obesity research & clinical practice, 2021 - Elsevier
baicalin ameliorates high fat diet (HFD)-induced obesity and … of baicalin for 8 h increases
peroxisome proliferator-activated … as free energy to muscle, liver, BAT and other tissues to …