Chemotherapy induces dynamic immune responses in breast cancers that impact treatment outcome
To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole
transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer
cohort of 146 patients including 110 pairs of serial tumor biopsies collected before treatment,
after the first cycle of treatment and at the time of surgery. Here, we show that cytotoxic
chemotherapies induce dynamic changes in the tumor immune microenvironment that vary
by subtype and pathologic response. Just one cycle of treatment induces an immune …
transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer
cohort of 146 patients including 110 pairs of serial tumor biopsies collected before treatment,
after the first cycle of treatment and at the time of surgery. Here, we show that cytotoxic
chemotherapies induce dynamic changes in the tumor immune microenvironment that vary
by subtype and pathologic response. Just one cycle of treatment induces an immune …
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