… To isolate the relevant downstream molecules, we performed a whole genome microarray
and mass spectrometry analysis, which led to the isolation of Chitinase-3-like-1 (CHI3L1) as …

… To isolate the relevant downstream molecules, we performed a whole genome microarray
and mass spectrometry analysis, which led to the isolation of Chitinase-3-like-1 (CHI3L1) as …

… identified in gene arrays of the GD mouse spleen, YKL40, also known as chitinase-3-like-1
(… progranulin, a regulator of CH3L1, which was recently proposed as a potential biomarker […

… ), progranulin (GRN) and microtubule-associated protein tau (MAPT). Research conducted
in this thesis focused on progranulin-… reduced levels of the progranulin protein (PGRN), …

… Prognostic biomarkers help triage initial patients and inform targeted therapy selection.
Here, we explored the role of progranulin (PGRN)—implicated in processes ranging from …

… the serum proteins closely associated with the COVID-19 severity. We observed 23 proteins
to … and specificity for their possible use as independent biomarkers to provide information on …

… in progranulin (GRN), microtubule associated protein tau (MAPT) … and lysosomal enzymes
as potential biomarkers of disease … , visinin-like protein-1, and chitinase-3-like protein 1 in mild …

… “Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker …
the identification and characterization of this new molecule may lead to innovative diagnostic …

… In addition, another study also identified a PGRN downstream molecule chitinase-3-like
Protein 1 (CHI3L1) as a novel biomarker for diagnosis and treatment efficacy surveillance of GD […

… Efforts to define these modifiers have led to identification of numerous molecules involved
in the regulation of GD pathogenicity, including molecules that influence GCase trafficking, …