Chojalactones A–C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium
The soil-derived bacterium, Streptomyces sp. CJ-5, was cocultured with the mycolic acid-
containing bacterium Tsukamurella pulmonis TP-B0596. The combined culture method
significantly enhanced the production of the secondary metabolites in Streptomyces sp. CJ-
5, leading to the isolation of three novel butanolide chojalactones A–C (1–3), with unusual γ-
butyrolactone scaffolds. The complete structures, including the absolute configurations of 1–
3, were determined based on spectroscopic data and total syntheses. In methylthiazole …
containing bacterium Tsukamurella pulmonis TP-B0596. The combined culture method
significantly enhanced the production of the secondary metabolites in Streptomyces sp. CJ-
5, leading to the isolation of three novel butanolide chojalactones A–C (1–3), with unusual γ-
butyrolactone scaffolds. The complete structures, including the absolute configurations of 1–
3, were determined based on spectroscopic data and total syntheses. In methylthiazole …
[引用][C] Chojalactones A–C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium
H Shotaro, W Toshiyuki, O Hiroyasu, A Ikuro - 2015
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