[HTML][HTML] Chromatin assembly factor 1 suppresses epigenetic reprogramming toward adaptive drug resistance
The long-term effectiveness of targeted cancer therapies is limited by the development of
resistance. Although epigenetic reprogramming has been implicated in resistance, the
mechanisms remain elusive. Herein, we demonstrate that increased chromatin accessibility
is involved in adaptive BRAF inhibitor (BRAFi)-resistance in melanoma cells. We observed
loss of chromatin assembly factor 1 (CAF-1) and its related histone H3 lysine 9 trimethylation
(H3K9me3) with adaptive BRAFi resistance. We further showed that depletion of CAF-1 …
resistance. Although epigenetic reprogramming has been implicated in resistance, the
mechanisms remain elusive. Herein, we demonstrate that increased chromatin accessibility
is involved in adaptive BRAF inhibitor (BRAFi)-resistance in melanoma cells. We observed
loss of chromatin assembly factor 1 (CAF-1) and its related histone H3 lysine 9 trimethylation
(H3K9me3) with adaptive BRAFi resistance. We further showed that depletion of CAF-1 …
以上显示的是最相近的搜索结果。 查看全部搜索结果