Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens
Background Chromothripsis is a recently discovered phenomenon of genomic
rearrangement, possibly arising during a single genome-shattering event. This could
provide an alternative paradigm in cancer development, replacing the gradual accumulation
of genomic changes with a “one-off” catastrophic event. However, the term has been used
with varying operational definitions, with the minimal consensus being a large number of
locally clustered copy number aberrations. The mechanisms underlying these …
rearrangement, possibly arising during a single genome-shattering event. This could
provide an alternative paradigm in cancer development, replacing the gradual accumulation
of genomic changes with a “one-off” catastrophic event. However, the term has been used
with varying operational definitions, with the minimal consensus being a large number of
locally clustered copy number aberrations. The mechanisms underlying these …
Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens.
CHY Cai HaoYang, NK Nitin Kumar, HC Bagheri… - 2014 - cabidigitallibrary.org
Background: Chromothripsis is a recently discovered phenomenon of genomic
rearrangement, possibly arising during a single genome-shattering event. This could
provide an alternative paradigm in cancer development, replacing the gradual accumulation
of genomic changes with a" one-off" catastrophic event. However, the term has been used
with varying operational definitions, with the minimal consensus being a large number of
locally clustered copy number aberrations. The mechanisms underlying these …
rearrangement, possibly arising during a single genome-shattering event. This could
provide an alternative paradigm in cancer development, replacing the gradual accumulation
of genomic changes with a" one-off" catastrophic event. However, the term has been used
with varying operational definitions, with the minimal consensus being a large number of
locally clustered copy number aberrations. The mechanisms underlying these …
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