Chronic Infection by Mucoid Pseudomonas aeruginosa Associated with Dysregulation in T-Cell Immunity to Outer Membrane Porin F
KJ Quigley, CJ Reynolds, A Goudet… - American Journal of …, 2015 - atsjournals.org
Rationale: Pseudomonas aeruginosa (PA) is an environmental pathogen that commonly
infects individuals with cystic fibrosis (CF) and non-CF bronchiectasis, impacting morbidity
and mortality. To understand the pathobiology of interactions between the bacterium and
host adaptive immunity and to inform rational vaccine design, it is important to understand
the adaptive immune correlates of disease. Objectives: To characterize T-cell immunity to
the PA antigen outer membrane porin F (OprF) by analyzing immunodominant epitopes in …
infects individuals with cystic fibrosis (CF) and non-CF bronchiectasis, impacting morbidity
and mortality. To understand the pathobiology of interactions between the bacterium and
host adaptive immunity and to inform rational vaccine design, it is important to understand
the adaptive immune correlates of disease. Objectives: To characterize T-cell immunity to
the PA antigen outer membrane porin F (OprF) by analyzing immunodominant epitopes in …
[PDF][PDF] Chronic Infection by Mucoid Pseudomonas aeruginosa Associated with Dysregulation in T Cell Immunity to OprF
KJ Quigley, CJ Reynolds, A Goudet… - Am J Respir Crit Care …, 2015 - core.ac.uk
Rationale. Pseudomonas aeruginosa (PA) is an environmental pathogen that commonly
infects individuals with cystic fibrosis (CF) and non-CF bronchiectasis, impacting on
morbidity and mortality. To understand the pathobiology of interactions between the
bacterium and host adaptive immunity and to inform rational vaccine design, it is important to
understand the adaptive immune correlates of disease. Objectives. We characterized T cell
immunity to the PA antigen, outer membrane porin F (OprF), analyzing immunodominant …
infects individuals with cystic fibrosis (CF) and non-CF bronchiectasis, impacting on
morbidity and mortality. To understand the pathobiology of interactions between the
bacterium and host adaptive immunity and to inform rational vaccine design, it is important to
understand the adaptive immune correlates of disease. Objectives. We characterized T cell
immunity to the PA antigen, outer membrane porin F (OprF), analyzing immunodominant …
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