Chronic microdose lithium treatment prevented memory loss and neurohistopathological changes in a transgenic mouse model of Alzheimer's disease

MA Nunes, NM Schoewe, KC Monteiro-Silva… - PloS one, 2015 - journals.plos.org
The use of lithium is well established in bipolar disorders and the benefits are being
demonstrated in neurodegenerative disorders. Recently, our group showed that treatment
with microdose lithium stabilized the cognitive deficits observed in Alzheimer's disease (AD)
patients. In order to verify the lithium microdose potential in preventing the disease
development, the aim of this work was to verify the effects of chronic treatment with
microdose lithium given before and after the appearance of symptoms in a mouse model of …

Correction: Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

MA Nunes, NM Schöwe, KC Monteiro-Silva… - PloS one, 2015 - journals.plos.org
There is an error within the fourth sentence of the Abstract. The correct sentence is:
Transgenic mice (Cg-Tg (PDGFB-APPSwInd) 20Lms/2J) and their non-transgenic litter mate
genetic controls were treated with lithium carbonate (0.25 mg/Kg/day in drinking water) for
16 or 8 months starting at two and ten months of age, respectively. There is an error within
the first sentence of the second paragraph of the Results and Discussion section. The
correct sentence is: Lithium was administered as lithium carbonate in the dose 0.25 …
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