Circadian changes in alzheimer's disease: neurobiology, clinical problems, and therapeutic opportunities
The understanding of Alzheimer's disease (AD) pathophysiology is an active area of
research, and the traditional focus on hippocampus, amyloid and tau protein, and memory
impairment has been expanded with components like neuroinflammation, insulin resistance,
and circadian rhythm alterations. The bidirectional vicious cycle of neuroinflammation and
neurodegeneration on a molecular level may cause functional deficits already long before
the appearance of overt clinical symptoms. Located at the crossroads of metabolic …
research, and the traditional focus on hippocampus, amyloid and tau protein, and memory
impairment has been expanded with components like neuroinflammation, insulin resistance,
and circadian rhythm alterations. The bidirectional vicious cycle of neuroinflammation and
neurodegeneration on a molecular level may cause functional deficits already long before
the appearance of overt clinical symptoms. Located at the crossroads of metabolic …
Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities
DF Swaab, F Kreier, PJ Lucassen… - The Human …, 2021 - books.google.com
The understanding of Alzheimer's disease (AD) pathophysiology is an active area of
research, and the traditional focus on hippocampus, amyloid and tau protein, and memory
impairment has been expanded with components like neuroinflammation, insulin resistance,
and circadian rhythm alterations. The bidirectional vicious cycle of neuroinflammation and
neurodegeneration on a molecular level may cause functional deficits already long before
the appearance of overt clinical symptoms. Located at the crossroads of metabolic …
research, and the traditional focus on hippocampus, amyloid and tau protein, and memory
impairment has been expanded with components like neuroinflammation, insulin resistance,
and circadian rhythm alterations. The bidirectional vicious cycle of neuroinflammation and
neurodegeneration on a molecular level may cause functional deficits already long before
the appearance of overt clinical symptoms. Located at the crossroads of metabolic …
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