[HTML][HTML] Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses
DT Leung, TR Bhuiyan, NS Nishat… - PLoS neglected …, 2014 - journals.plos.org
PLoS neglected tropical diseases, 2014•journals.plos.org
Background Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in
abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-
adaptive interface. Methods We measured MAIT cell frequencies and antibody responses in
blood from patients presenting with culture-confirmed severe cholera to a hospital in Dhaka,
Bangladesh at days 2, 7, 30, and 90 of illness. Results We found that MAIT (CD3+ CD4−
CD161hiVα7. 2+) cells were maximally activated at day 7 after onset of cholera. In adult …
abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-
adaptive interface. Methods We measured MAIT cell frequencies and antibody responses in
blood from patients presenting with culture-confirmed severe cholera to a hospital in Dhaka,
Bangladesh at days 2, 7, 30, and 90 of illness. Results We found that MAIT (CD3+ CD4−
CD161hiVα7. 2+) cells were maximally activated at day 7 after onset of cholera. In adult …
Background
Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface.
Methods
We measured MAIT cell frequencies and antibody responses in blood from patients presenting with culture-confirmed severe cholera to a hospital in Dhaka, Bangladesh at days 2, 7, 30, and 90 of illness.
Results
We found that MAIT (CD3+CD4−CD161hiVα7.2+) cells were maximally activated at day 7 after onset of cholera. In adult patients, MAIT frequencies did not change over time, whereas in child patients, MAITs were significantly decreased at day 7, and this decrease persisted to day 90. Fold changes in MAIT frequency correlated with increases in LPS IgA and IgG, but not LPS IgM nor antibody responses to cholera toxin B subunit.
Conclusions
In the acute phase of cholera, MAIT cells are activated, depleted from the periphery, and as part of the innate response against V. cholerae infection, are possibly involved in mechanisms underlying class switching of antibody responses to T cell-independent antigens.
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