Abstract A 10-year-old, spayed, female poodle was presented at Prasuarthon Animal Hospital, Faculty of Veterinary Science, Mahidol University for further investigation on abdominal enlargement, anorexia and frequent vomiting for 1 week. Upon an abdominal palpation, a firm abdominal mass was noted in the cranial abdomen. Hematology and blood chemistry values were within normal limits, except elevated symmetric dimethylarginine (SDMA). Ultrasonography reported a large oval shaped mass at the left retroperitoneal area of unknown origin. The computed tomography (CT) result revealed that the left kidney was severely enlarged with an irregular shape. The dog was diagnosed with a renal mass. An exploratory laparotomy and nephrectomy were performed for diagnosis and treatment. The renal mass was submitted for a histopathological examination and was reported to be a clear cell renal cell carcinoma (ccRCC). The patient was clinically healthy and was under follow up for 24 weeks without any sign of metastasis.