illness consistent clinically with severe malaria but with negative blood smears pose a
management dilemma. Malaria pigment is evident in peripheral blood leukocytes in greater
than 90% of patients with severe malaria. To characterize the clearance kinetics of
parasitized erythrocytes and malaria pigment-containing leukocytes, sequential peripheral
blood and intradermal smears were assessed in 27 adult Vietnamese patients with severe …