The paper focuses on the role of multilevel governance in climate change adaptation and risk management, and draws out lessons from the implementation of the UN Habitat Cities and Climate Change Initiatives (CCCI) in Bobo-Dioulasso, Burkina Faso. It describes the process for the formulation of a participatory risk management framework for local actors drawing from empirical investigations undertaken in Bobo-Dioulasso. The paper argues that adaptation needs to be mainstreamed and implemented at local level and to include risk management. Moreover, regulatory capacity of public authorities and balance of power and resources play a major role in this process. After presenting the specific knowledge on climate and environmental challenges and CCCI implementation in Bobo-Dioulasso, the paper describes challenges and opportunities in the implementation of the participatory risk and management framework.