Clinical effects and pharmacokinetic variables of romifidine and the peripheral α2‐adrenoceptor antagonist MK‐467 in horses
A de Vries, SAE Pakkanen, MR Raekallio… - Veterinary anaesthesia …, 2016 - Elsevier
Objectives To investigate the effects of MK‐467 on sedation quality, and cardiopulmonary
and pharmacokinetic variables in horses sedated intravenously (IV) with romifidine. Study
design Experimental, randomized, crossover design. Animals Seven healthy mares.
Methods Romifidine (80 μg kg− 1; R) and MK‐467 (200 μg kg− 1; MK) were administered IV
alone and in combination (R+ MK). Levels of sedation and borborygmi were scored. Heart
rate (HR), direct arterial blood pressure (ABP) and respiratory rate (f R) were recorded …
and pharmacokinetic variables in horses sedated intravenously (IV) with romifidine. Study
design Experimental, randomized, crossover design. Animals Seven healthy mares.
Methods Romifidine (80 μg kg− 1; R) and MK‐467 (200 μg kg− 1; MK) were administered IV
alone and in combination (R+ MK). Levels of sedation and borborygmi were scored. Heart
rate (HR), direct arterial blood pressure (ABP) and respiratory rate (f R) were recorded …
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