Osteoporosis, a major skeletal disorder characterized by decreased bone mass, predominantly affects women and has a major impact on public health. Fractures due to bone fragility are the most important complications of osteoporosis. The main objectives of the optimal management of osteoporosis are to increase muscle strength and strengthen bones, respectively to reduce the risk of falls, trauma and fractures. In the rehabilitation treatment of osteoporotic patients, physical therapy is essential. In this study we aimed to demonstrate that the treatment of osteoporosis by combining the drugs with a physical therapy program for one year has superior therapeutic effects compared to the simple drug treatment performed in the same period of time. Two groups of patients were enrolled: the study group (39 subjects who underwent home physiotherapy) and the control group (43 subjects who did not undergo home physiotherapy). The results highlighted the superior therapeutic benefits of drug treatment associated with an appropriate physical therapy program.