Clinico-pathological parameters of 50 oral squamous cell carcinoma cases in Karachi
M Alamgir, Q Jamal, NA Jafarey… - Pakistan Journal of …, 2013 - ojs.zu.edu.pk
M Alamgir, Q Jamal, NA Jafarey, T Mirza
Pakistan Journal of Medicine and Dentistry, 2013•ojs.zu.edu.pkBackground: The incidence of oral squamous cell carcinoma remains high in Indo-Pak
region. Worldwide oral and oropharyngeal carcinomas are the sixth most common cancers.
A number of clinic-pathological parameters have been implicated in prognosis, recurrence
and survival for this tumor. As a very high frequency reported in major hospitals of Karachi,
this study documented some of the well known clinicpathological parameters in the
indigenous population of Karachi. Objective: To analyze the clinicopathological parameters …
region. Worldwide oral and oropharyngeal carcinomas are the sixth most common cancers.
A number of clinic-pathological parameters have been implicated in prognosis, recurrence
and survival for this tumor. As a very high frequency reported in major hospitals of Karachi,
this study documented some of the well known clinicpathological parameters in the
indigenous population of Karachi. Objective: To analyze the clinicopathological parameters …
Background
The incidence of oral squamous cell carcinoma remains high in Indo-Pak region. Worldwide oral and oropharyngeal carcinomas are the sixth most common cancers. A number of clinic-pathological parameters have been implicated in prognosis, recurrence and survival for this tumor. As a very high frequency reported in major hospitals of Karachi, this study documented some of the well known clinicpathological parameters in the indigenous population of Karachi.
Objective
To analyze the clinicopathological parameters of cases of OSCC in the population of Karachi.
Methods
The study protocol was approved by the Ziauddin University ethics committee for human research. The patients’ data was entered onto questionnaires. The reporting included a range of clinical, operative and histopathological variables. Recurrence of tumor after initial treatment was also documented.
Results
The patients’ population comprised 31 males and 19 females. The mean age was 45.56 (SD + 12.08). Minimum age was 15 years, while maximum was 75 years. Pathological analysis revealed that majority of SCC cases were moderately differentiated SCC with clinical stage T2 or T3, N0,M0/N1,M0. Most common oral sites came out to be buccal mucosa of cheeks followed by lateral borders of tongue and lips. All patients underwent primary resection ± neck dissection and reconstruction when necessary.
Conclusion
Overall experience with OSCC shows that it has a high tendency to disseminate to regional lymph nodes, i.e. cervical lymph nodes, as well as to re-emerge at the primary site after resection. Key Words: Oral Squamous Cell Carcinoma, Clinico-Pathological Parameters, Clinical Stage.
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