Cobalt (ii) catalyzed C (sp)–H bond functionalization of alkynes with phenyl hydrazines: facile access to diaryl 1, 2-diketones
Organic & Biomolecular Chemistry, 2015•pubs.rsc.org
A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C (sp)–H bond
functionalization has been described. The reaction involves a free-radical mechanism,
wherein the phenyl radical formed from phenyl hydrazine couples with Co (II) activated
alkyne to produce 1, 2-diketones. The reaction proceeds at room temperature in DMF with
the use of Ag2O/air as the oxidizing system. The utility of the protocol for the synthesis of a
series of imidazoles including a potent platelet aggregation inhibitor trifenagrel has been …
functionalization has been described. The reaction involves a free-radical mechanism,
wherein the phenyl radical formed from phenyl hydrazine couples with Co (II) activated
alkyne to produce 1, 2-diketones. The reaction proceeds at room temperature in DMF with
the use of Ag2O/air as the oxidizing system. The utility of the protocol for the synthesis of a
series of imidazoles including a potent platelet aggregation inhibitor trifenagrel has been …
A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)–H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples with Co(II) activated alkyne to produce 1,2-diketones. The reaction proceeds at room temperature in DMF with the use of Ag2O/air as the oxidizing system. The utility of the protocol for the synthesis of a series of imidazoles including a potent platelet aggregation inhibitor trifenagrel has been demonstrated.
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