CofActor: A light-And stress-gated optogenetic clustering tool to study disease-associated cytoskeletal dynamics in living cells
The hallmarks of neurodegenerative diseases, including neural fibrils, reactive oxygen
species, and cofilin–actin rods, present numerous challenges in the development of in vivo
diagnostic tools. Biomarkers such as β-amyloid (Aβ) fibrils and Tau tangles in Alzheimer's
disease are accessible only via invasive cerebrospinal fluid assays, and reactive oxygen
species can be fleeting and challenging to monitor in vivo. Although remaining a challenge
for in vivo detection, the protein–protein interactions underlying these disease-specific …
species, and cofilin–actin rods, present numerous challenges in the development of in vivo
diagnostic tools. Biomarkers such as β-amyloid (Aβ) fibrils and Tau tangles in Alzheimer's
disease are accessible only via invasive cerebrospinal fluid assays, and reactive oxygen
species can be fleeting and challenging to monitor in vivo. Although remaining a challenge
for in vivo detection, the protein–protein interactions underlying these disease-specific …
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