Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA
Abstract Cohesin SA1 (STAG1) and SA2 (STAG2) are key components of the cohesin
complex. Previous studies have highlighted the unique contributions by SA1 and SA2 to 3D
chromatin organization, DNA replication fork progression, and DNA double-strand break
(DSB) repair. Recently, we discovered that cohesin SA1 and SA2 are DNA binding proteins.
Given the recently discovered link between SA2 and RNA-mediated biological pathways, we
investigated whether or not SA1 and SA2 directly bind to RNA using a combination of bulk …
complex. Previous studies have highlighted the unique contributions by SA1 and SA2 to 3D
chromatin organization, DNA replication fork progression, and DNA double-strand break
(DSB) repair. Recently, we discovered that cohesin SA1 and SA2 are DNA binding proteins.
Given the recently discovered link between SA2 and RNA-mediated biological pathways, we
investigated whether or not SA1 and SA2 directly bind to RNA using a combination of bulk …
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