Combination Effects of Salvianolic Acid B with Low-Dose Celecoxib on Inhibition of Head and Neck Squamous Cell Carcinoma Growth In vitro and In vivo
Y Zhao, Y Hao, H Ji, Y Fang, Y Guo, W Sha… - Cancer Prevention …, 2010 - AACR
Head and neck squamous cell carcinoma (HNSCC) development is closely associated with
inflammation. Cyclooxygenase-2 (COX-2) is an important mediator of inflammation.
Therefore, celecoxib, a selective inhibitor of COX-2, was hailed as a promising
chemopreventive agent for HNSCC. Dose-dependent cardiac toxicity limits long-term use of
celecoxib, but it seems likely that this may be diminished by lowering its dose. We found that
salvianolic acid B (Sal-B), isolated from Salvia miltiorrhiza Bge, can effectively suppress …
inflammation. Cyclooxygenase-2 (COX-2) is an important mediator of inflammation.
Therefore, celecoxib, a selective inhibitor of COX-2, was hailed as a promising
chemopreventive agent for HNSCC. Dose-dependent cardiac toxicity limits long-term use of
celecoxib, but it seems likely that this may be diminished by lowering its dose. We found that
salvianolic acid B (Sal-B), isolated from Salvia miltiorrhiza Bge, can effectively suppress …
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