[PDF][PDF] Combined effect of electroporation and miltefosine on keratinocyte cell line HaCaT
A Kostadinova, B Nikolova, P Handjiiska… - Romanian Reports in …, 2015 - researchgate.net
Romanian Reports in Physics, 2015•researchgate.net
In this study we investigated the effect of combined treatment of HaCaT keratinocyte cells
with electrical pulses (200–500V/cm) and the alkylphosholipid (ALP) miltefosine. The data
show that electroporation in combination with miltefosine induces cytoskeleton disruption
and increases the permeability of cell monolayers due to interruption of cell-cell junctions',
as documented by fluorescent imaging of ZO-1 and actin integrity. This was accompanied
with reduction of cell viability. The combination of these conditions could be considered as a …
with electrical pulses (200–500V/cm) and the alkylphosholipid (ALP) miltefosine. The data
show that electroporation in combination with miltefosine induces cytoskeleton disruption
and increases the permeability of cell monolayers due to interruption of cell-cell junctions',
as documented by fluorescent imaging of ZO-1 and actin integrity. This was accompanied
with reduction of cell viability. The combination of these conditions could be considered as a …
Abstract
In this study we investigated the effect of combined treatment of HaCaT keratinocyte cells with electrical pulses (200–500V/cm) and the alkylphosholipid (ALP) miltefosine. The data show that electroporation in combination with miltefosine induces cytoskeleton disruption and increases the permeability of cell monolayers due to interruption of cell-cell junctions’, as documented by fluorescent imaging of ZO-1 and actin integrity. This was accompanied with reduction of cell viability. The combination of these conditions could be considered as a method for treating several types of skin cancer or other pathological conditions affecting the skin integrity.
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