Background: Folate and methionine play a crucial role in DNA synthesis, repair and the
epigenetic profile of cell. Hence, the alterations in the folate metabolism can lead to aberrant
proliferation leading to neoplasia. Most of the studies have associated polymorphisms in
methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR)
genes with reduced risk of cervical and colorectal cancer. However, the association with
breast cancer is still controversial. Further, the involvement of Glutamate carboxypeptidase II …

… Further, the involvement of Glutamate carboxypeptidase II (GCPII) polymorphism in
cancer is not known. In the present study, we analyzed if the individual and combined
effects of polymorphisms in folate pathway genes viz., MTHFR 677C > T, MTHFR 1298A > C,
MTRR 66A > G and GCP II 1561 C>T, have any role in altering the susceptibility to breast
cancer. … Since the data on genetic polymorphisms in one carbon metabolism pathway for
breast cancer susceptibility is inconclusive and con.icting, we carried a pilot study to …