Wetland ecosystem structure and function are primarily governed by water regime. Characterizing past and current wetland hydrology is thus crucial for identifying the drivers of long-term wetland degradation. Critically, a lack of spatially distributed and long-term field-measured data has impeded such characterization in most wetland systems across the world. The publically accessible Moderate Resolution Imaging Spectroradiometer (MODIS) satellite products encode spatial and temporal data for landscape monitoring, but it was unclear whether it could be used to reliably predict the hydric status of wetland due to the mixture of spectral signatures existing within and between such systems. We proposed and tested a methodological framework for the identification of site-specific wetness status spectral identification rule (WSSIR) using two recent technical innovations: affordable, easily deployable field water level sensors to train the WSSIR with supervised learning, and the powerful cloud-based Google Earth Engine (GEE) platform to rapidly access and process the MODIS imagery. This methodological framework was used in a study case of the globally important Palo Verde National Park tropical wetland in Costa Rica. Results showed that a site-specific WISSR could reliably detect wetland wet or dry status (hydroperiod) and capture the temporal variability of the wetness status. We applied it on the 500 m 2000-2016 MODIS Land Surface Reflectance daily product to reconstruct hydroperiod history, hence reaching a temporal resolution rarely matched in remote sensing for environmental studies. The analysis of the resulting long-term, spatially distributed MODIS-derived data, coupled with shorterterm, 15-minute resolution field water level time-series provided new insights into the drivers controlling the spatiotemporal dynamics of hydrology within Palo Verde National Park’s degrading wetlands. This new knowledge is critical to make informed restoration and management decisions. Specifically, we identified a significant influence of the surrounding rivers and irrigation district, which emphasised the importance of considering the wetland in the watershed context when elaborating management strategies. The methodological framework can be applied to any other mid-to large-scale wetland systems worldwide.