Common data elements to standardize genomics studies in cerebral palsy
YA Wilson, H Smithers‐Sheedy… - … Medicine & Child …, 2022 - Wiley Online Library
Developmental Medicine & Child Neurology, 2022•Wiley Online Library
Aim To define clinical common data elements (CDEs) and a mandatory minimum data set
(MDS) for genomic studies of cerebral palsy (CP). Method Candidate data elements were
collated following a review of the literature and existing CDEs. An online, three‐round
Delphi survey was used to rate each data element as either 'core','recommended','
exploratory', or 'not required'. Members of the International Cerebral Palsy Genomics
Consortium (ICPGC) rated the core CDEs as either mandatory or not, to form the MDS. For …
(MDS) for genomic studies of cerebral palsy (CP). Method Candidate data elements were
collated following a review of the literature and existing CDEs. An online, three‐round
Delphi survey was used to rate each data element as either 'core','recommended','
exploratory', or 'not required'. Members of the International Cerebral Palsy Genomics
Consortium (ICPGC) rated the core CDEs as either mandatory or not, to form the MDS. For …
Aim
To define clinical common data elements (CDEs) and a mandatory minimum data set (MDS) for genomic studies of cerebral palsy (CP).
Method
Candidate data elements were collated following a review of the literature and existing CDEs. An online, three‐round Delphi survey was used to rate each data element as either ‘core’, ‘recommended’, ‘exploratory’, or ‘not required’. Members of the International Cerebral Palsy Genomics Consortium (ICPGC) rated the core CDEs as either mandatory or not, to form the MDS. For both the CDEs and the MDS, a data element was considered to have reached consensus if more than 75% of respondents agreed.
Results
Forty‐six individuals from around the world formed the Delphi panel: consumers (n=2), scientists/researchers (n=17), medical (n=19), and allied health professionals (n=8). The CDEs include 107 data elements across six categories: demographics, diagnostics, family history, antenatal and neonatal details, clinical traits, and CP‐specific assessments. Of these, 10 are mandatory, 42 core, 41 recommended, and 14 are exploratory.
Interpretation
The ICPGC CDEs provide a foundation for the standardization of phenotype data captured in CP genomic studies and will benefit international collaborations and pooling of data, particularly in rare conditions.
What this paper adds
- A set of 107 common data elements (CDEs) for genomics studies in cerebral palsy is provided.
- The CDEs include standard definitions and data values domains.
- The CDEs will facilitate international data sharing, collaboration, and improved clinical interpretation of findings.
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