Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation
M Granell, A Urbano-Ispizua, A Pons… - Blood, The Journal …, 2008 - ashpublications.org
The inflammasomes are macromolecular cytosolic complexes involved in the production of
interleukin-1β (IL-1β) and IL-18 in response to several pathogen-derived stimuli. Such
interleukins have been implicated in the origin of severe allogeneic stem cell transplant (allo-
SCT) complications. We analyzed the relationship between the interindividual variability in
inflammasome protein-encoding genes in donors and patients and clinical outcome after
allo-SCT. Fourteen common genetic variants in 5 genes of the inflammasome, namely …
interleukin-1β (IL-1β) and IL-18 in response to several pathogen-derived stimuli. Such
interleukins have been implicated in the origin of severe allogeneic stem cell transplant (allo-
SCT) complications. We analyzed the relationship between the interindividual variability in
inflammasome protein-encoding genes in donors and patients and clinical outcome after
allo-SCT. Fourteen common genetic variants in 5 genes of the inflammasome, namely …
[PDF][PDF] Common variants in NLRP2 and NLRP3 genes are strong prognostic
M Rovira, E Carreras, C Rozman, M Juan, J Yague… - researchgate.net
The inflammasomes are macromolecular cytosolic complexes involved in the production of
IL-1β and IL-18 in response to several pathogen-derived stimuli. Such interleukines have
been implicated in the origin of severe allogeneic stem cell transplant (allo-SCT)
complications. We analysed the relationship between the interindividual variability in
inflammasome protein-encoding genes in donors and patients and clinical outcome after
allo-SCT. Fourteen common genetic variants in five genes of the inflammasome, namely …
IL-1β and IL-18 in response to several pathogen-derived stimuli. Such interleukines have
been implicated in the origin of severe allogeneic stem cell transplant (allo-SCT)
complications. We analysed the relationship between the interindividual variability in
inflammasome protein-encoding genes in donors and patients and clinical outcome after
allo-SCT. Fourteen common genetic variants in five genes of the inflammasome, namely …
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