Comparative evaluation of ibuprofen/β-cyclodextrin complexes obtained by supercritical carbon dioxide and other conventional methods
K Hussein, M Türk, MA Wahl - Pharmaceutical research, 2007 - Springer
K Hussein, M Türk, MA Wahl
Pharmaceutical research, 2007•SpringerPurpose The preparation of drug/cyclodextrin complexes is a suitable method to improve the
dissolution of poor soluble drugs. The efficacy of the Controlled Particle Deposition (CPD) as
a new developed method to prepare these complexes in a single stage process using
supercritical carbon dioxide is therefore compared with other conventional methods.
Materials and Methods Ibuprofen/β-cyclodextrin complexes were prepared with different
techniques and characterized using FTIR-ATR spectroscopy, powder X-ray diffractometry …
dissolution of poor soluble drugs. The efficacy of the Controlled Particle Deposition (CPD) as
a new developed method to prepare these complexes in a single stage process using
supercritical carbon dioxide is therefore compared with other conventional methods.
Materials and Methods Ibuprofen/β-cyclodextrin complexes were prepared with different
techniques and characterized using FTIR-ATR spectroscopy, powder X-ray diffractometry …
Purpose
The preparation of drug/cyclodextrin complexes is a suitable method to improve the dissolution of poor soluble drugs. The efficacy of the Controlled Particle Deposition (CPD) as a new developed method to prepare these complexes in a single stage process using supercritical carbon dioxide is therefore compared with other conventional methods.
Materials and Methods
Ibuprofen/β-cyclodextrin complexes were prepared with different techniques and characterized using FTIR-ATR spectroscopy, powder X-ray diffractometry (PXRD), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). In addition, the influences of the processing technique on the drug content (HPLC) and the dissolution behavior were studied.
Results
Employing the CPD-process resulted in a drug content of 2.8 ± 0.22 wt.% in the carrier. The material obtained by CPD showed an improved dissolution rate of ibuprofen at pH 5 compared with the pure drug and its physical mixture with β-cyclodextrin. In addition CPD material displays the highest dissolution (93.5 ± 2.89% after 75 min) compared to material obtained by co-precipitation (61.3 ± 0.52%) or freeze-drying (90.6 ± 2.54%).
Conclusion
This study presents the CPD-technique as a well suitable method to prepare a drug/β-cyclodextrin complex with improved drug dissolution compared to the pure drug and materials obtained by other methods.
Springer
以上显示的是最相近的搜索结果。 查看全部搜索结果