Comparison of outcomes for open versus endoscopic approaches for olfactory neuroblastoma: a systematic review and individual participant data meta‐analysis

TS Fu, E Monteiro, N Muhanna, DP Goldstein… - Head & …, 2016 - Wiley Online Library
TS Fu, E Monteiro, N Muhanna, DP Goldstein, JR de Almeida
Head & neck, 2016•Wiley Online Library
Background Endoscopic approaches have been adopted as an alternative to craniofacial
resection in the surgical management of olfactory neuroblastoma. Methods We conducted a
systematic review and meta‐analysis using MEDLINE, EMBASE, Cochrane, and CINAHL
(2000–2014) to compare outcomes for open versus endoscopic approaches. Results Thirty‐
six studies containing 609 patients were included. Meta‐analysis of (a) all patients,(b)
Kadish C/D only, and (c) Hyams III/IV only, failed to show a difference in locoregional control …
Background
Endoscopic approaches have been adopted as an alternative to craniofacial resection in the surgical management of olfactory neuroblastoma.
Methods
We conducted a systematic review and meta‐analysis using MEDLINE, EMBASE, Cochrane, and CINAHL (2000–2014) to compare outcomes for open versus endoscopic approaches.
Results
Thirty‐six studies containing 609 patients were included. Meta‐analysis of (a) all patients, (b) Kadish C/D only, and (c) Hyams III/IV only, failed to show a difference in locoregional control and metastasis‐free survival between approaches. However, endoscopic approaches were associated with improved overall survival (OS) for all 3 groups (p = .001, .04, and .001, respectively), and higher disease‐specific survival (DSS) for all patients (p = .004) and Hyams III/IV only (p = .002).
Conclusion
The current study suggests that endoscopic approaches have comparable control rates to open approaches for olfactory neuroblastoma. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2306–E2316, 2016
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