Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from
pregnancy exposure and in adults from personal smoking. Whether a unique methylation
signature exists for in utero exposure in newborns is unknown. Materials & methods: We
separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k
Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648
newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts …
pregnancy exposure and in adults from personal smoking. Whether a unique methylation
signature exists for in utero exposure in newborns is unknown. Materials & methods: We
separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k
Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648
newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts …
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