The relationships among formation properties, fracturing operations, and induced earthquakes nucleated at distinctive moments and positions remain unclear. In this study, a complete data set on formations, seismicity, and fracturing treatments is collected in Fox Creek, Alberta, Canada. The data set is then used to characterize the induced seismicity and evaluate its susceptibility toward fracturing stimulations via integration of geology, geomechanics, and hydrology. Five mechanisms are identified to account for spatiotemporal activation of the nearby faults in Fox Creek, where all major events [with a moment magnitude (M w) greater than 2.5] are caused by the increase in pore pressure and poroelastic stress during the fracturing operation. In addition, an integrated geological index (IGI) and a combined geomechanical index (CGI) are first proposed to indicate seismicity susceptibility, which is consistent with the spatial distribution of induced earthquakes. Finally, mitigation strategy results suggest that enlarging a hydraulic fracture-fault distance and decreasing a fracturing job size can reduce the risk of potential seismic activities.