Comprehensive screening of heterocyclic compound libraries to identify novel inhibitors for PfRIO-2 kinase through docking and substrate competition studies
Malaria is most prevalent in tropical climate and causes 1–3 million deaths annually. RIO-2
kinase, an atypical kinase regulates ribosome biogenesis and is necessary for cell cycle
progression. Structural characterization of PFD0975w (PfRIO-2 kinase) indicates N-terminal
DNA binding winged helix domain (1–84), a linker region (85–147), and C-terminal kinase
domain (148–275). Heterocyclic compounds present in different databases represent an
enormous reservoir to screen and develop the suitable inhibitor. An extensive screening of …
kinase, an atypical kinase regulates ribosome biogenesis and is necessary for cell cycle
progression. Structural characterization of PFD0975w (PfRIO-2 kinase) indicates N-terminal
DNA binding winged helix domain (1–84), a linker region (85–147), and C-terminal kinase
domain (148–275). Heterocyclic compounds present in different databases represent an
enormous reservoir to screen and develop the suitable inhibitor. An extensive screening of …
Comprehensive screening of heterocyclic compound libraries to identify novel inhibitors for PfRIO-2 kinase through docking and substrate competition studies.
SN Swagata Nag, DK Chouhan, SN Balaji… - 2013 - cabidigitallibrary.org
Malaria is most prevalent in tropical climate and causes 1-3 million deaths annually. RIO-2
kinase, an atypical kinase regulates ribosome biogenesis and is necessary for cell cycle
progression. Structural characterization of PFD0975w (PfRIO-2 kinase) indicates N-terminal
DNA binding winged helix domain (1-84), a linker region (85-147), and C-terminal kinase
domain (148-275). Heterocyclic compounds present in different databases represent an
enormous reservoir to screen and develop the suitable inhibitor. An extensive screening of …
kinase, an atypical kinase regulates ribosome biogenesis and is necessary for cell cycle
progression. Structural characterization of PFD0975w (PfRIO-2 kinase) indicates N-terminal
DNA binding winged helix domain (1-84), a linker region (85-147), and C-terminal kinase
domain (148-275). Heterocyclic compounds present in different databases represent an
enormous reservoir to screen and develop the suitable inhibitor. An extensive screening of …