Computational approach for calculating the probability of eukaryotic translation initiation from ribo-seq data that takes into account leaky scanning
AM Michel, DE Andreev, PV Baranov - BMC bioinformatics, 2014 - Springer
Background Ribosome profiling (ribo-seq) provides experimental data on the density of
elongating or initiating ribosomes at the whole transcriptome level that can be potentially
used for estimating absolute levels of translation initiation at individual Translation Initiation
Sites (TISs). These absolute levels depend on the mutual organisation of TISs within
individual mRNAs. For example, according to the leaky scanning model of translation
initiation in eukaryotes, a strong TIS downstream of another strong TIS is unlikely to be …
elongating or initiating ribosomes at the whole transcriptome level that can be potentially
used for estimating absolute levels of translation initiation at individual Translation Initiation
Sites (TISs). These absolute levels depend on the mutual organisation of TISs within
individual mRNAs. For example, according to the leaky scanning model of translation
initiation in eukaryotes, a strong TIS downstream of another strong TIS is unlikely to be …
[PDF][PDF] Computational approach for calculating the probability of
AM Michel, DE Andreev, PV Baranov - 2014 - cora.ucc.ie
Background: Ribosome profiling (ribo-seq) provides experimental data on the density of
elongating or initiating ribosomes at the whole transcriptome level that can be potentially
used for estimating absolute levels of translation initiation at individual Translation Initiation
Sites (TISs). These absolute levels depend on the mutual organisation of TISs within
individual mRNAs. For example, according to the leaky scanning model of translation
initiation in eukaryotes, a strong TIS downstream of another strong TIS is unlikely to be …
elongating or initiating ribosomes at the whole transcriptome level that can be potentially
used for estimating absolute levels of translation initiation at individual Translation Initiation
Sites (TISs). These absolute levels depend on the mutual organisation of TISs within
individual mRNAs. For example, according to the leaky scanning model of translation
initiation in eukaryotes, a strong TIS downstream of another strong TIS is unlikely to be …
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