Concomitant PPARα and FXR activation as a putative mechanism of NASH improvement after gastric bypass surgery: a GEO datasets analysis
Background Compared to non-surgical weight loss (Diet), weight loss after Roux-en-Y
gastric bypass (RYGB) results in greater rates of non-alcoholic steatohepatitis (NASH)
resolution. Changes in bile acid physiology and farnesoid X receptor (FXR) signaling are
suspected mediators of postoperative NASH improvement. Recent experimental evidence
suggests that upregulation of hepatic peroxisome proliferator-activated receptor α (PPARα)
activity might also impact NASH improvement. As FXR partly regulates PPARα, we …
gastric bypass (RYGB) results in greater rates of non-alcoholic steatohepatitis (NASH)
resolution. Changes in bile acid physiology and farnesoid X receptor (FXR) signaling are
suspected mediators of postoperative NASH improvement. Recent experimental evidence
suggests that upregulation of hepatic peroxisome proliferator-activated receptor α (PPARα)
activity might also impact NASH improvement. As FXR partly regulates PPARα, we …
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