Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation 'bath salt'α-pyrrolidinopentiophenone (α-PVP)
KH Nelson, BJ Hempel, MM Clasen, KC Rice… - Pharmacology …, 2017 - Elsevier
Background α-Pyrrolidinopentiophenone (α-PVP) has been reported to be rewarding in a
variety of pre-clinical models. Given that a number of drugs of abuse have both rewarding
and aversive effects, the balance of which influences addiction potential, the present study
examined the aversive properties of α-PVP by assessing its ability to induce taste
avoidance. This assessment was made in a combined taste avoidance/place conditioning
design that also allowed an evaluation of the relationship between α-PVP's aversive and …
variety of pre-clinical models. Given that a number of drugs of abuse have both rewarding
and aversive effects, the balance of which influences addiction potential, the present study
examined the aversive properties of α-PVP by assessing its ability to induce taste
avoidance. This assessment was made in a combined taste avoidance/place conditioning
design that also allowed an evaluation of the relationship between α-PVP's aversive and …
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