[图书][B] Conformational equilibrium of human growth hormone: a mechanism for the self-association of the intermediate state
MR Kasimova - 2000 - search.proquest.com
2000•search.proquest.com
The structural stability of recombinant human growth hormone (rhGH) has been studied by
spectroscopic and calorimetric methods. These studies demonstrate that the
folding/unfolding equilibrium of rhGH involves a partially folded dimeric intermediate. At acid
pH (pH 3) the formation of this intermediate is a reversible process. At higher pH values
reversibility is not observed and the intermediate state has a higher propensity towards
oligomerization.
spectroscopic and calorimetric methods. These studies demonstrate that the
folding/unfolding equilibrium of rhGH involves a partially folded dimeric intermediate. At acid
pH (pH 3) the formation of this intermediate is a reversible process. At higher pH values
reversibility is not observed and the intermediate state has a higher propensity towards
oligomerization.
Abstract
The structural stability of recombinant human growth hormone (rhGH) has been studied by spectroscopic and calorimetric methods. These studies demonstrate that the folding/unfolding equilibrium of rhGH involves a partially folded dimeric intermediate. At acid pH (pH 3) the formation of this intermediate is a reversible process. At higher pH values reversibility is not observed and the intermediate state has a higher propensity towards oligomerization.
ProQuest以上显示的是最相近的搜索结果。 查看全部搜索结果