Metastatic bone disease (MBD) commonly heralds the final progression of many cancers.
Skeletal-related events (SRE) represent symptomatic bone metastases and usually present
as pain, fracture, spinal cord compression, and hypercalcemia of malignancy. As patients
with advanced disease live longer due to therapeutic advances, the number of patients with
metastatic bone disease is increasing. The optimal management of MBD and SRE requires
a coordinated team effort including specialists from surgical and nonsurgical disciplines …