Continuous-time deep glioma growth models

J Petersen, F Isensee, G Köhler, PF Jäger… - … Image Computing and …, 2021 - Springer
Medical Image Computing and Computer Assisted Intervention–MICCAI 2021: 24th …, 2021Springer
The ability to estimate how a tumor might evolve in the future could have tremendous clinical
benefits, from improved treatment decisions to better dose distribution in radiation therapy.
Recent work has approached the glioma growth modeling problem via deep learning and
variational inference, thus learning growth dynamics entirely from a real patient data
distribution. So far, this approach was constrained to predefined image acquisition intervals
and sequences of fixed length, which limits its applicability in more realistic scenarios. We …
Abstract
The ability to estimate how a tumor might evolve in the future could have tremendous clinical benefits, from improved treatment decisions to better dose distribution in radiation therapy. Recent work has approached the glioma growth modeling problem via deep learning and variational inference, thus learning growth dynamics entirely from a real patient data distribution. So far, this approach was constrained to predefined image acquisition intervals and sequences of fixed length, which limits its applicability in more realistic scenarios. We overcome these limitations by extending Neural Processes, a class of conditional generative models for stochastic time series, with a hierarchical multi-scale representation encoding including a spatio-temporal attention mechanism. The result is a learned growth model that can be conditioned on an arbitrary number of observations, and that can produce a distribution of temporally consistent growth trajectories on a continuous time axis. On a dataset of 379 patients, the approach successfully captures both global and finer-grained variations in the images, exhibiting superior performance compared to other learned growth models.
Springer
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