A major goal in synthetic development is to design and construct gene regulatory circuits
that control the patterning and morphogenesis of synthetic multicellular structures. In natural
development, an interplay between mechanical and chemical communication shapes the
dynamics of gene regulatory circuits that underlie patterning and morphogenesis. However,
for synthetic gene circuits, how the non-genetic properties of the growth environment impact
circuit behavior remains poorly understood. Here, we describe an occurrence of mechano …

A major goal in synthetic development is to build gene regulatory circuits that control
patterning. In natural development, an interplay between mechanical and chemical
communication shapes the dynamics of multicellular gene regulatory circuits. For synthetic
circuits, how non-genetic properties of the growth environment impact circuit behavior
remains poorly explored. Here, we first describe an occurrence of mechano-chemical
coupling in synthetic Notch (synNotch) patterning circuits: high cell density decreases …