Core fucosylation regulates epidermal growth factor receptor-mediated intracellular signaling
α1, 6-Fucosyltransferase (Fut8) catalyzes the transfer of a fucose residue to N-linked
oligosaccharides on glycoproteins via an α1, 6-linkage to form core fucosylation in
mammals. We recently found that disruption of the Fut8 gene induces severe growth
retardation and early postnatal death. To investigate the molecular mechanism involved, we
have established embryonic fibroblasts of Fut8+/+ and Fut8–/–, derived from wild-type and
Fut8-null mice, respectively. Interestingly, the epidermal growth factor (EGF)-induced …
oligosaccharides on glycoproteins via an α1, 6-linkage to form core fucosylation in
mammals. We recently found that disruption of the Fut8 gene induces severe growth
retardation and early postnatal death. To investigate the molecular mechanism involved, we
have established embryonic fibroblasts of Fut8+/+ and Fut8–/–, derived from wild-type and
Fut8-null mice, respectively. Interestingly, the epidermal growth factor (EGF)-induced …
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