Coronary artery disease-associated genetic variants and biomarkers of inflammation
MK Christiansen, SB Larsen, M Nyegaard… - PloS one, 2017 - journals.plos.org
MK Christiansen, SB Larsen, M Nyegaard, S Neergaard-Petersen, R Ajjan, M Würtz…
PloS one, 2017•journals.plos.orgIntroduction Genetic constitution and inflammation both contribute to development of
coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms
(SNPs) have recently been identified, but their functions are largely unknown. We
investigated the associations between CAD-associated SNPs and five CAD-related
inflammatory biomarkers. Methods We genotyped 45 CAD-associated SNPs in 701 stable
CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6 …
coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms
(SNPs) have recently been identified, but their functions are largely unknown. We
investigated the associations between CAD-associated SNPs and five CAD-related
inflammatory biomarkers. Methods We genotyped 45 CAD-associated SNPs in 701 stable
CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6 …
Introduction
Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown. We investigated the associations between CAD-associated SNPs and five CAD-related inflammatory biomarkers.
Methods
We genotyped 45 CAD-associated SNPs in 701 stable CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6, calprotectin, fibrinogen and complement component 3 levels had previously been measured. A genetic risk score was calculated to assess the combined risk associated with all the genetic variants. A multiple linear regression model was used to assess associations between the genetic risk score, single SNPs, and the five inflammatory biomarkers.
Results
The minor allele (G) (CAD risk allele) of rs2075650 (TOMM40/APOE) was associated with lower levels of high-sensitivity C-reactive protein (effect per risk allele: -0.37 mg/l [95%CI -0.56 to -0.18 mg/l]). The inflammatory markers tested showed no association with the remaining 44 SNPs or with the genetic risk score.
Conclusions
In stable CAD patients, the risk allele of a common CAD-associated marker at the TOMM40/APOE locus was associated with lower hsCRP levels. No other genetic variants or the combined effect of all variants were associated with the five inflammatory biomarkers.
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