Correlating tau pathology to brain atrophy using a physics-based Bayesian model
Misfolded tau proteins are a classical hallmark of Alzheimer's disease. Increasing evidence
indicates that tau—and not amyloid—is the main agent in driving neurodegeneration and
tissue atrophy in Alzheimer's brains. However, the precise correlation between tau and
atrophy remains insufficiently understood. Here we explore tau-atrophy interactions by
integrating a multiphysics brain network model and longitudinal neuroimaging data for n= 61
subjects from the Alzheimer's Disease Neuroimaging Initiative. Using Bayesian inference …
indicates that tau—and not amyloid—is the main agent in driving neurodegeneration and
tissue atrophy in Alzheimer's brains. However, the precise correlation between tau and
atrophy remains insufficiently understood. Here we explore tau-atrophy interactions by
integrating a multiphysics brain network model and longitudinal neuroimaging data for n= 61
subjects from the Alzheimer's Disease Neuroimaging Initiative. Using Bayesian inference …
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