Correlation of intact sensibility and neuropathic pain-related behaviors in eight inbred and outbred rat strains and selection lines
Y Shir, R Zeltser, JJ Vatine, G Carmi, I Belfer, A Zangen… - Pain, 2001 - Elsevier
In some rat strains, total hindpaw denervation triggers autotomy, a behavior of self mutilation
presumably related to neuropathic pain. Partial sciatic ligation (PSL) in rats produces tactile
allodynia and heat hyperalgesia but not autotomy. Our aims in this study were to
examine:(1) whether sensibility of intact rats to noxious and non-noxious stimuli is strain-
dependent;(2) whether sensibility of intact rats could predict levels of autotomy, or of
allodynia and hyperalgesia in the PSL model; and (3) whether autotomy levels are …
presumably related to neuropathic pain. Partial sciatic ligation (PSL) in rats produces tactile
allodynia and heat hyperalgesia but not autotomy. Our aims in this study were to
examine:(1) whether sensibility of intact rats to noxious and non-noxious stimuli is strain-
dependent;(2) whether sensibility of intact rats could predict levels of autotomy, or of
allodynia and hyperalgesia in the PSL model; and (3) whether autotomy levels are …
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