Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages
S Biswas, M Adrian, K Evdokimov… - Biochemical and …, 2015 - Elsevier
Liver endothelial differentiation-associated protein-1 (Leda-1/Pianp) is a type-I-
transmembrane protein that is able to bind and activate immune inhibitory receptor Pilrα.
Here we show that Leda-1/Pianp is strain-specifically expressed in lymphoid organs and
macrophages of Th2-prone BALB/c mice but not of Th1-prone C57BL/6J mice. LPS
stimulation of BALB/c bone marrow-derived macrophages (BMM) and macrophage-like Raw
264.7 cells conversely regulated Leda-1/Pianp and Pilrα expression. Pilrα induction was …
transmembrane protein that is able to bind and activate immune inhibitory receptor Pilrα.
Here we show that Leda-1/Pianp is strain-specifically expressed in lymphoid organs and
macrophages of Th2-prone BALB/c mice but not of Th1-prone C57BL/6J mice. LPS
stimulation of BALB/c bone marrow-derived macrophages (BMM) and macrophage-like Raw
264.7 cells conversely regulated Leda-1/Pianp and Pilrα expression. Pilrα induction was …
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