Critical regulation of Th17 cell differentiation by serum amyloid-A signalling in Behcet's disease
The current understandings on cellular and molecular biology suggest that Th17 axis plays
a pivotal role in Behcet's disease (BD) pathogenesis. Recently the role of serum amyloid-A
(SAA) as a potential marker of disease activity in BD patients has been explored, and it has
been reported that the occurrence of specific clinical features are significantly associated
with high serum levels of this inflammatory mediator. The aim of this study was to investigate
the cytokine-like activity of SAA in inducing Th17 differentiation from CD4+ T naive cells in …
a pivotal role in Behcet's disease (BD) pathogenesis. Recently the role of serum amyloid-A
(SAA) as a potential marker of disease activity in BD patients has been explored, and it has
been reported that the occurrence of specific clinical features are significantly associated
with high serum levels of this inflammatory mediator. The aim of this study was to investigate
the cytokine-like activity of SAA in inducing Th17 differentiation from CD4+ T naive cells in …