Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs
D Sinitski, K Gruner, M Brandhofer, C Kontos… - Journal of Biological …, 2020 - ASBMB
Human macrophage migration-inhibitory factor (MIF) is an evolutionarily-conserved protein
that has both extracellular immune-modulating and intracellular cell-regulatory functions.
MIF plays a role in various diseases, including inflammatory diseases, atherosclerosis,
autoimmunity, and cancer. It serves as an inflammatory cytokine and chemokine, but also
exhibits enzymatic activity. Secreted MIF binds to cell-surface immune receptors such as
CD74 and CXCR4. Plants possess MIF orthologs but lack the associated receptors …
that has both extracellular immune-modulating and intracellular cell-regulatory functions.
MIF plays a role in various diseases, including inflammatory diseases, atherosclerosis,
autoimmunity, and cancer. It serves as an inflammatory cytokine and chemokine, but also
exhibits enzymatic activity. Secreted MIF binds to cell-surface immune receptors such as
CD74 and CXCR4. Plants possess MIF orthologs but lack the associated receptors …
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