Crosstalk between trace elements and T-cell immunity during early-life health in pigs

S Jin, L He, C Yang, X He, H Chen, Y Feng… - Science China Life …, 2023 - Springer
S Jin, L He, C Yang, X He, H Chen, Y Feng, W Tang, J Li, D Liu, T Li
Science China Life Sciences, 2023Springer
With gradual ban on the use of antibiotics, the deficiency and excessive use of trace
elements in intestinal health is gaining attention. In mammals, trace elements are essential
for the development of the immune system, specifically T-cell proliferation, and
differentiation. However, there remain significant gaps in our understanding of the effects of
certain trace elements on T-cell immune phenotypes and functions in pigs. In this review, we
summarize the specificity, development, subpopulations, and responses to pathogens of …
Abstract
With gradual ban on the use of antibiotics, the deficiency and excessive use of trace elements in intestinal health is gaining attention. In mammals, trace elements are essential for the development of the immune system, specifically T-cell proliferation, and differentiation. However, there remain significant gaps in our understanding of the effects of certain trace elements on T-cell immune phenotypes and functions in pigs. In this review, we summarize the specificity, development, subpopulations, and responses to pathogens of porcine T cells and the effects of functional trace elements (e.g., iron, copper, zinc, and selenium) on intestinal T-cell immunity during early-life health in pigs. Furthermore, we discuss the current trends of research on the crosstalk mechanisms between trace elements and T-cell immunity. The present review expands our knowledge of the association between trace elements and T-cell immunity and provides an opportunity to utilize the metabolism of trace elements as a target to treat various diseases.
Springer
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