Crystal structure of malaria parasite nucleosome assembly protein

J Gill, M Yogavel, A Kumar, H Belrhali, SK Jain… - Journal of Biological …, 2009 - ASBMB
… motors of malaria parasites, which can serve as essential targets for antimalarials. The
human malaria parasite P. falciparum contains two nucleosome assembly proteins, which we …

Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

J Gill, A Kumar, M Yogavel, H Belrhali, SK Jain, M Rug… - Malaria journal, 2010 - Springer
… study, the structural basis of nucleosome assembly activity in … the crystal structure of smaller
NAP in the parasite called … on both malaria parasite nucleosome assembly proteins, it is …

[PDF][PDF] Crystal structure of malaria parasite nucleosome assembly protein: Distinct Modes Of Protein Localization And Histone...

Y Manickam, A Kumar, S Jain, M Brown - J. Biol. Chem, 2009 - academia.edu
… The human malaria parasite P. falciparum contains two nucleosome assembly proteins, …
Our published reports on the two Plasmodium parasite nucleosome assembly proteins have …

Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning

E Silberhorn, U Schwartz, P Löffler, S Schmitz… - PLoS …, 2016 - journals.plos.org
… (B) Crystal structure 1AOI of the human nucleosome, marking … the nucleosomal DNA for
efficient nucleosome assembly. Three … the parasite nucleosomes less efficient than the human …

Histone globular domain epigenetic modifications: The regulators of chromatin dynamics in malaria parasite

CA Jabeena, A Rajavelu - ChemBioChem, 2024 - Wiley Online Library
nucleosome assembly proteins which help to assemble the histones into functional nucleosomes
(… extend to the outside of the nucleosomal disk, as revealed by the crystal structure of …

Nucleosome structures built from highly divergent histones: parasites and giant DNA viruses

S Sato, M Dacher, H Kurumizaka - Epigenomes, 2022 - mdpi.com
… In addition, X-ray crystallographic analyses have shown that the basic residues in … a
nucleosome assembly protein (NAP1)-like protein have been identified among the secreted proteins

Peculiarities of Plasmodium falciparum Gene Regulation and Chromatin Structure

MT Watzlowik, S Das, M Meissner… - International Journal of …, 2021 - mdpi.com
… of the human malaria parasite, Plasmodium falciparum, is … Crystal structures of Pf nucleosomes
are not available so far, … between chromatin proteins in humans and Plasmodium will …

The malaria parasite Plasmodium falciparum histones: organization, expression, and acetylation

J Miao, Q Fan, L Cui, J Li, J Li, L Cui - Gene, 2006 - Elsevier
proteins that are involved in nucleosome assembly and regulation of chromatin structures (…
, which are not visible in the crystal structure of the nucleosome structure but are the targets of …

Structure of prolyl-tRNA synthetase-halofuginone complex provides basis for development of drugs against malaria and toxoplasmosis

V Jain, M Yogavel, Y Oshima, H Kikuchi, B Touquet… - Structure, 2015 - cell.com
Plasmodium parasites are the causative agents of malaria, with an … ), which attach amino
acids onto cognate tRNAs for protein … as nucleosome assembly and lipid import in the malaria

Structural insights into histone chaperone Asf1 and its characterization from Plasmodium falciparum

DK Srivastava, S Gunjan, C Das, V Seshadri… - Biochemical …, 2021 - portlandpress.com
nucleosome assembly/disassembly process. We observed that … the uniquely evolved malarial
parasite Plasmodium falciparum. … To determine the crystal structure of PfAsf1–NTD, we first …