In the last few years, it has become clear that a wide variety of environmental contaminants
have specific effects on neuroendocrine systems in fish, amphibians, birds and mammals.
While it is beyond the scope of this review to provide a comprehensive examination of all of
these neuroendocrine disruptors, we will focus on select representative examples.
Organochlorine pesticides bioaccumulate in neuroendocrine areas of the brain that directly
regulate GnRH neurons, thereby altering the expression of genes downstream of GnRH …