Curving cells inside and out: roles of BAR domain proteins in membrane shaping and its cellular implications

M Simunovic, E Evergren… - Annual review of cell …, 2019 - annualreviews.org
Many cellular processes rely on precise and timely deformation of the cell membrane. While
many proteins participate in membrane reshaping and scission, usually in highly specialized
ways, Bin/amphiphysin/Rvs (BAR) domain proteins play a pervasive role, as they not only
participate in many aspects of cell trafficking but also are highly versatile membrane
remodelers. Subtle changes in the shape and size of the BAR domain can greatly impact the
way in which BAR domain proteins interact with the membrane. Furthermore, the activity of …
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