Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery
C Madhu, C Voshavar, K Rajasekhar… - Organic & biomolecular …, 2017 - pubs.rsc.org
Organic & biomolecular chemistry, 2017•pubs.rsc.org
An unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell
penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of
Kkd-5 resulted in serum stability, non-toxicity to cells, and interaction with membrane and
DNA, all of which facilitated efficient cellular uptake and DNA delivery.
penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of
Kkd-5 resulted in serum stability, non-toxicity to cells, and interaction with membrane and
DNA, all of which facilitated efficient cellular uptake and DNA delivery.
An unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of Kkd-5 resulted in serum stability, non-toxicity to cells, and interaction with membrane and DNA, all of which facilitated efficient cellular uptake and DNA delivery.
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