Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress
Cylindrospermopsin (CYN), a potent cyanobacterial cytototoxin produced by certain
freshwater cyanobacteria, is regularly found in water supplies in many parts of the world,
and has been associated with the intoxication of humans and livestock. The few genotoxicity
studies available indicate that CYN is genotoxic, generally implying that it is pro-genotoxic.
In human peripheral blood lymphocytes (HPBLs) CYN (0, 0.05, 0.1 and 0.5 μg/ml) induced
the formation of DNA single strand breaks, applying the comet assay. Time and dose …
freshwater cyanobacteria, is regularly found in water supplies in many parts of the world,
and has been associated with the intoxication of humans and livestock. The few genotoxicity
studies available indicate that CYN is genotoxic, generally implying that it is pro-genotoxic.
In human peripheral blood lymphocytes (HPBLs) CYN (0, 0.05, 0.1 and 0.5 μg/ml) induced
the formation of DNA single strand breaks, applying the comet assay. Time and dose …
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